AD-mix

AD-mix in organic chemistry is a commercially available mixture of reagents for performing amongst others the Sharpless asymmetric dihydroxylation of alkenes. The mix is available in two variations, "AD-mix α" and "AD-mix β" following ingredient lists published by Sharpless.^[1] As such it is used in research laboratories.

Additional recommended knowledge

How to ensure accurate weighing results every day?

What is the Sensitivity of my Balance?

Safe Weighing Range Ensures Accurate Results

The mixes contain:

• Potassium osmate K₂OsO₂(OH)₄ as the source of Osmium tetroxide
• Potassium ferricyanide K₃Fe(CN)₆, which is the re-oxidant in the catalytic cycle
• Potassium carbonate
• Chiral ligands (see below)

In AD-mix α (DHQ)₂PHAL (top) is the phthalazine adduct with dihydroquinine.

In AD-mix β; (DHQD)₂PHAL is the phthalazine adduct with dihydroquinidine.

See also

• Reagent
• Sharpless asymmetric dihydroxylation

References