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ACVR1B



Activin receptor type 1B
Other names: ACTR-IB, Serine/threonine-protein kinase receptor R2, SKR2, Activin receptor-like kinase 4, ALK-4
Genetic data
Gene code: HUGO code: ACVR1B
Protein Structure/Function
Protein type: Serine/Threonine receptor kinase
Domains: GS domain, TS domain, S/T domain
Other
Taxa expressing:Homo sapiens; homologs: many metazoan phyla
Cell types:ubiquitous
Subcellular localization:Plasma membrane
Enzymatic Data
Catalytic activity:ATP + (receptor-protein) = ADP + (receptor-protein) phosphate
Cofactor(s):Magnesium or manganese
Medical/Biotechnological data
Diseases:Pancreatic Carcinoma

ACVR1B or ALK-4 acts as a transducer of Activin or activin like ligands (eg. Inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.[1] ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto[2].

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Identifiers
Symbol ACVR1B
Alt. Symbols ACVRLK4
Entrez 91
HUGO 172
OMIM 601300
RefSeq NM_020328
UniProt P36896
Other data
EC number 2.7.11.30
Locus Chr. 12 q13

References

  1. ^ Inman, GJ; Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. (Jul 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol Pharmacol. 62 (1). Entrez PubMed 12065756. Retrieved on 2006-07-05.
  2. ^ Harrison, CA; Gray PC, Koerber SC, Fischer W, Vale W (Jun 2003). "Identification of a functional binding site for activin on the type I receptor ALK4". J Biol Chem. 278 (23). Entrez PubMed 12665502. Retrieved on 2006-07-05.
v • d • e
Cell signaling: TGF beta signaling pathway
TGF beta superfamily of ligandsTGF beta family (TGF-β1, TGF-β2, TGF-β3)
Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15)
Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15)
Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal)
TGF beta receptorsTGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B)
TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2
TGFBR3: betaglycan
Transducers/SMADR-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand InhibitorsCerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
CoreceptorsBAMBI - Cripto
OtherSARA
  This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ACVR1B". A list of authors is available in Wikipedia.
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