7-Aminoactinomycin

7-aminoactinomycin (7-ADD) is a fluorescent DNA intercalator marketed by several companies including AnaSpec, Invitrogen, and Biotium. It binds double stranded DNA and can be excited by an argon-ion laser to emit light at 647 nm wavelength. It binds GC regions selectively,^[1] making it useful for chromosome banding studies.^[2]

References

1. ^ Liu X, Chen H, Patel D (1991). "Solution structure of actinomycin-DNA complexes: drug intercalation at isolated G-C sites". J Biomol NMR 1 (4): 323-47. PMID 1841703.
2. ^ Latt S (1977). "Fluorescent probes of chromosome structure and replication". Can J Genet Cytol 19 (4): 603-23. PMID 76502.